Consider an $n$ qubit density matrix $\rho$ such that
$$\text{Tr}(|\psi\rangle\langle \psi| ~\rho) \leq \frac{1}{2^{n}} + \mathcal{O}\left(\frac{1}{2^{2n}} \right), $$
for every $n$ qubit pure state $|\psi \rangle$.
Is there some way to argue that the density matrix is close to the maximally mixed state, with respect to some distance measure?
Note that the maximally mixed state trivially satisfies this requirement.