Let us consider a protocol between Alice and Bob. Alice works in a $2^n$-dimensional Hilbert space $\mathcal{H}_A$, using $n$ qubits. Bob works in a $(1+2^n)$-dimensional Hilbert space using qdits. For instance, for $n=128$, Bob would work with two high-dimensional qdits, since $1+2^{128}$ is the product of two large primes.
Since $\mathcal{H}_B$ is isomorphic to $\mathbb{C}^{2^n+1}$, it is possible to write any state $|\psi\rangle_{\mathcal{H}_B}\in\mathcal{H}_B$ as: $$|\psi\rangle_{\mathcal{H}_B}=\sum_{i=0}^{2^n}\psi_i|i\rangle_{\mathcal{H}_B}\,.$$
Let us say that Alice prepares the following state: $$|\varphi\rangle_{\mathcal{H}_A} = \sum_{i=0}^{2^n-1}\varphi_i|i\rangle_{\mathcal{H}_A}$$ and sends it to Bob. Now, Bob wants to transform this state into: $$|\varphi\rangle_{\mathcal{H}_B} = \sum_{i=0}^{2^n-1}\varphi_i|i\rangle_{\mathcal{H}_B}+0\left|2^n\right\rangle_{\mathcal{H}_B}$$ and to apply an unitary matrix $\mathbf{U}_{\mathcal{H}_B}$ such that $\mathbf{U}_{\mathcal{H}_B}\left|2^n\right\rangle_{\mathcal{H}_B}=\left|2^n\right\rangle_{\mathcal{H}_B}$ and $\mathbf{U}_{\mathcal{H}_B}^\dagger\left|2^n\right\rangle_{\mathcal{H}_B}=\left|2^n\right\rangle_{\mathcal{H}_B}$ (that is, $\mathbf{U}_{\mathcal{H}_B}$ does not add the $\left|2^n\right\rangle_{\mathcal{H}_B}$ state in the superposition for any other state and is defined as the identity for this state). This would transform the state in : $$\mathbf{U}_{\mathcal{H}_B}|\varphi\rangle_{\mathcal{H}_B}=\sum_{i=0}^{2^n-1}\alpha_i|i\rangle_{\mathcal{H}_B}\,.$$ Finally, Bob transforms back this quantum state into a $n$-qubit quantum state and sends it back to Alice.
Does this make sense? Is it possible to consider such a protocol, where one converts a quantum state lying in an Hilbert space to one in another Hilbert space?