Short Answer: There is no universal gate that can entangle the output state for any given ? and ??? operators in the circuit given in the question.
Long Answer:
Say you have the entangle state $|\psi\rangle = \alpha |00\rangle + \beta |11\rangle$ before applying the ??? operator. Let the ??? operator correspond to the matrix $M = \begin{bmatrix}m_1 & m_2 \\ m_3 & m_4\end{bmatrix}$. So once you apply $M$ on the first qubit of $|\psi\rangle$, you get the state $$\hat{|\psi\rangle} = (M\otimes I)|\psi\rangle = \alpha(m_1|0\rangle + m_3|1\rangle)|0\rangle + \beta(m_2|0\rangle + m_4|1\rangle)|1\rangle.$$ Now, we need an operator $U$ that acts on the second qubit of $\hat{|\psi\rangle}$ to give us a state of the form $|\psi'\rangle = \alpha' |00\rangle + \beta' |11\rangle$. Let $U = \begin{bmatrix}u_1 & u_2 \\ u_3 & u_4\end{bmatrix}$. The operation of $U$ on the second qubit of $\hat{|\psi\rangle}$ can be given as $$\begin{align}(I \times U)\hat{|\psi\rangle} &= \big[\alpha(m_1|0\rangle + m_3|1\rangle)(u_1|0\rangle + u_3|1\rangle)\big] + \big[\beta(m_2|0\rangle + m_4|1\rangle)(u_2|0\rangle + u_4|1\rangle)\big] \\
&= (\alpha~m_1 u_1 + \beta~m_2u_2)|00\rangle + (\alpha~m_1 u_3 + \beta~m_2u_4)|01\rangle\\
& ~~~~+ (\alpha~m_3 u_1 + \beta~m_4u_2)|10\rangle + (\alpha~m_3 u_3 + \beta~m_4u_4)|11\rangle \end{align}$$
Now, notice that if the operator $U$ is such that the amplitudes of $|01\rangle$ and $|10\rangle$ are zero then we achieve an entangled state. Mathematically, we need $$\alpha~m_1 u_3 + \beta~m_2u_4 = 0 ~~\text{ and }~~ \alpha~m_3 u_1 + \beta~m_4u_2 = 0\tag{1}\label{eqn:1}.$$
It is a well known fact that any single qubit operator $A$ can be represented as $A = \begin{bmatrix}\cos{(\theta/2)} & -e^{i\lambda}\sin{(\theta/2)}\\ e^{i\phi}\sin{(\theta/2)} & e^{i(\lambda+\phi)}\cos{(\theta/2)}\end{bmatrix}$ (For more information on this check $U_3$ gates.) Using this notation we can write the operators $M$ and $U$ as $$M = \begin{bmatrix}\cos{(\theta_m/2)} & -e^{i\lambda_m}\sin{(\theta_m/2)}\\ e^{i\phi_m}\sin{(\theta_m/2)} & e^{i(\lambda_m+\phi_m)}\cos{(\theta_m/2)}\end{bmatrix} \text{ ; } U = \begin{bmatrix}\cos{(\theta_u/2)} & -e^{i\lambda_u}\sin{(\theta_u/2)}\\ e^{i\phi_u}\sin{(\theta_u/2)} & e^{i(\lambda_u+\phi_u)}\cos{(\theta_u/2)}\end{bmatrix}$$
Using this notation and solving for the first equation of ($\ref{eqn:1}$), we get $$\alpha~m_1u_3 + \beta~m_2u_4 = 0 \iff \alpha\cos{(\theta_m/2)}\sin{(\theta_u/2)} = e^{i(\lambda_m+\lambda_u)}\beta\sin{(\theta_m/2)}\cos{(\theta_u/2)} \tag{2}\label{eqn:2}$$
Similarly for the second equation of ($\ref{eqn:1}$), we get $$\alpha~m_3u_1 + \beta~m_4u_2 = 0 \iff \alpha\sin{(\theta_m/2)}\cos{(\theta_u/2)} = e^{i(\lambda_m+\lambda_u)}\beta\cos{(\theta_m/2)}\sin{(\theta_u/2)}\tag{3}\label{eqn:3}$$
So if you apply an operator $U$ that satisfies the conditions ($\ref{eqn:2}$) and ($\ref{eqn:3}$), then the final state will still be an entangled state of the form $\alpha'|00\rangle + \beta' |11\rangle$. If any gate that violates ($\ref{eqn:2}$) and ($\ref{eqn:3}$) is applied to the circuit, then you will not get an entangled state of the form $\alpha'|00\rangle + \beta' |11\rangle$. Hence you will need to know the ? and the ??? gates to get the output in the form $\alpha'|00\rangle + \beta' |11\rangle$ with certainty.